WebApr 19, 2024 · Here, we report that an elevation of FGF-2 signaling in samples from patients with nasopharyngeal carcinoma (NPC) and xenograft mouse models promoted NPC metastasis. Mechanistically, tumor cell–derived FGF-2 strongly promoted pericyte proliferation and pericyte-specific expression of an orphan chemokine (C-X-C motif) … WebApr 19, 2024 · We provide mechanistic insight into an FGF-2-FGFR1-pericyte-CXCL14-TAM stromal communication axis in NPC and propose an effective anti-metastasis therapy concept by targeting a pericyte-derived...
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WebResults: Circ_0004788 and fibroblast growth factor 2 (FGF2) were significantly elevated, and microRNA-515-5p (miR-515-5p) was dramatically decreased in NPC tissues and cells. … WebJun 15, 2000 · Furthermore, we show that FGF2 (fibroblast growth factor 2), one of the main regulators of CNS development, induces a dose-dependant increase of both the … settings button not working in windows 10
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WebIn this work we evaluated mouse neurospheres cultured with and without FGF-2 and EGF containing medium and showed that those growth factors are responsible for NPC … WebFGF2 is a direct transcriptional target of miR-16 in NPC. (A) Wild-type and mutant miR-16 target sequences of the FGF2 mRNA 3′-UTR. (B) Relative luciferase activities of the indicated cells... WebSecreted immunomodulatory factor expression of other factors was altered compared to NPC transplantation alone. Post-stroke depression-like behavior was reduced following cellular and material transplantation. ... TIE2, and FGF2 by microglia/macrophages (Fig. 4) suggests that CS-A encapsulation may promote microglia/macrophages to assist in ... the times musicals