WebThis study indicates that ONYX-015 injection via EUS into pancreatic carcinomas by the transgastic route with prophylactic antibiotics is feasible and generally well tolerated either alone or in combination with gemcitabine. Transgastric EUS-guided injection is a new and practical method of deliveri … WebONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. …
ONYX-015 selectivity and the p14ARF pathway Oncogene
WebO ONYX-015 (dl1520, CI-1042) é um adenovírus modificado que se replica seletivamente em células cancerígenas deficientes em p53, mas não em células normais (Bischoff, 1996). Ele é modificado a partir de um vírus que expressa a proteína da região precordial, E1B, que se liga e inativa a p53. Web5 de abr. de 2012 · The rapid subsequent clinical progression of an oncolytic adenovirus (ONYX-015) 28, 29 towards Phase III testing reflected the early promise of the field 30, 31, however despite proven safety, Adenovirus was felt to have insufficient anti-tumor effects and so researchers turned to more rapidly replicating and lytic viruses to act as the … bio-wheel filter
A Phase I/II Trial of Intratumoral Endoscopic Ultrasound Injection …
Web1 de dez. de 2007 · ONYX-015 is an attenuated chimeric human group C adenovirus, which preferentially replicates in and lyses tumor cells that are p53 negative. The purpose of this phase I, dose-escalation study was ... WebONYX-015, a gene-deleted adenovirus engineered to selectively replicate in and destroy P53-deficient cancer cells, has completed a phase II investigation in head and neck … Web1 de jun. de 1997 · It is reported that normal human cells were highly resistant to ONYX-015-mediated, replication-dependent cytolysis and a wide range of human tumor cells, including numerous carcinoma lines with either mutant or normal p53 gene sequences, were efficiently destroyed. The 55-kilodalton (kDa) protein from the E1B-region of adenovirus … dale of norway narvik merino wool sweater