Webb18 okt. 2024 · KINGSTON, R.I. – Oct. 18, 2024 – Researchers from the University of Rhode Island and Yale University have demonstrated a promising new approach to delivering immunotherapy agents to fight cancer. The approach involves tethering an immunotherapy agent called a STING agonist to an acid-seeking molecule called pHLIP® (pH-low … Webb1 feb. 2024 · Let's help you get started on your journey as a sought-after IT expert Learn from any part of the world Earn your certificate and be job-ready.

Oleg ANDREEV Professor (Full) Ph. D. - ResearchGate

Webb15 dec. 2024 · Herein, a pH low insertion peptide (pHLIP)-functionalized copolymer of polyethylenimine and polylactide (pHLIP-PEI-PLA) was synthesized and self-assembled … WebbpHLIP ® s (pH-Low Insertion Peptides) are a platform technology of pH-sensitive peptides that exploit pH differences between healthy and diseased cells as a biomarker for … bartuning

pHLIP, Inc

Webb3 nov. 2010 · The monomeric pHLIP inserts its C terminus across a membrane under slightly acidic conditions (pH 6–6.5), forming a transmembrane helix. The delivery construct carries phalloidin linked to its inserting C terminus via a disulfide bond that is cleaved inside cells, releasing the toxin. Webb16 nov. 2012 · Because pHLIP can deliver polar cell-impermeable molecules intracellularly, a number of new therapeutic compounds might be formulated. Moreover, pHLIP-coated liposomes might be used to deliver a mixture of pharmaceuticals to the risk zone. Thus, we assume that pHLIP technology might have a significant impact on the treatment of … WebbThe pHLIP platform can be applied to imaging acidic tissues, delivering cell-permeable and impermeable molecules to the cytoplasm, and promoting the cellular uptake of … sveg ica