WebbAs FDA-approved chemotherapeutic agents, cisplatin, oxaliplatin, and 5-fluorouracil are widely used in clinic but limited by severe side-effects. To ameliorate their respective defects, a series of “dual-prodrug” by linking oxoplatin and 5-FU were designed and synthesized. The assembled compounds 10–17, named Fuplatin, exhibited much ... Webb12 apr. 2024 · These drugs have become common causes of chemotherapy-related cardiotoxicity, resulting in adverse effects such as angina, myocardial infarction, heart failure, arrhythmias, and cardiac arrest. [ 2, 3] The enzyme thymidine phosphorylase converts capecitabine to 5-FU, and this enzyme is expressed in higher levels in …
Cancers Free Full-Text NF-κB Signaling in Targeting Tumor Cells …
Webb5 sep. 2024 · The anti-cancer effects of prodrugs of 5-FU (i.e., CAP and FT) and 5-FU itself were investigated in the four-organ system . Four cell lines – Caco-2, HepaRG, HCT-116, and TIG-121 – were used as models of intestine, liver, cancer, and connective tissue, respectively. Caco-2 ... WebbCapecitabine is a prodrug of 5-FU that is selectively activated in tumors overexpressing the activating enzyme thymidine phosporylase. 19 Additional antimetabolites include the cytosine arabinoside (Ara-C), 6-thioguanine, 6-mercaptopurine, and fludarabine. gold and silver jewellery co. ltd
Pharmaceutics Free Full-Text New Hybrid Scaffolds Based on 5-FU …
WebbThe in- Both 5-FU and lipophilic 5-FUSA Prodrug were encapsulated into the tensity ratio of the first peak (373 nm) and the third peak (384 nm) I373/ Xyl-SA NPs by dialysis method … Webb12 apr. 2024 · A series of 5-FU-Curcumin hybrids were synthesized, and their structures were elucidated by spectroscopic analysis. The synthesized hybrid compounds were evaluated in different colorectal cancer cell lines (SW480 and SW620) and in non-malignant cells (HaCaT and CHO-K1), to determine their chemopreventive potential. Hybrids 6a and … Webb18 apr. 1995 · 5-Fluorouracil (5-FU) is an effective antitumor agent used in treating various cancers. Because of its metabolism by intestinal and other cells, 5-FU has an … hbg humane society